It is common that I recommend acetaminophen (Tylenol) for pain relief, especially when a patient has sensitivity to aspirin and ibuprofen. Actually, acetaminophen is my first choice when I am in pain. For some people with coronary artery disease, taking 3 grams of Tylenol daily for 2 weeks can result in elevated blood pressure. This was reported in the February issue of the Harvard Heart Letter, based on a study by researchers in Switzerland. If you anticipate needing pain relief for greater than two weeks and you have cardiovascular disease, discuss pain medication alternatives with your doctor.